The aim of this study was to design, formulate and evaluate the physicochemical properties of zidovudine, lamivudine and nevirapine as effervescent tablets, since they can overcome problem with drug swallowing for pediatric, elder and bed-ridden patients. Effervescent tablet were prepared in dosage form 300 mg zidovudine, 150 mg lamivudine, 200 mg nevirapine, by wet granulation method. Pre-compression characteristics of the mixed powder and granules, such as angle of repose, compressibility index, mean particle size and hausner’s ratio were evaluated. Then they are evaluated for post compression properties including Weight variation, hardness, friability, carbon dioxide release, effervescent time, pH, content uniformity. All the formulation exhibited effervescent time less than 1 min 15 sec and dissolution profile was found to be more than 95% in 5 min. The stability study reveals that the product was stable at various temperature and humidity condition.
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